One of the first major outbreak cases occurred in Soho, England in 1854, taking part of the worldwide Cholera outbreak that lasted from 1846-1860. A man by the name of John Snow was a major factor in this outbreak, helping to bring an end to spread. Snow was able to separate himself from other scientists and researchers at the time and began focusing on other possible methods of transmission other than it being an airborne virus. He suspected that the agent of Cholera was a tiny agent – smaller than the naked eye can comprehend, capable of reproduction, and most likely had a structure similar to that of a cell. Snow’s discoveries eventually led him to believe that the disease correlated with the local drinking water in the area. With this possibility in mind John Snow mapped out all the local water pumps in the area and compared them to the location of Cholera deaths in the area. His findings showed a direct correlation between the two as most of the deaths surrounded a local pump located on Broad Street. Due to this he was able to convince the municipal authorities to stop usage of the Broad Street pump. At this time the number of cases and deaths were already on the decline, but even so, the methods used by Snow helped pave the way to epidemiology as we know it today. [4] 

• First, mapping out the Cholera deaths, followed by overlaying the point density of the deaths to see where the majority of the deaths took place. We will also calculate the mean center and directional distribution from the mean center.
• The next step is to figure out the relation between the deaths and trade pump areas using zonal statistics to determine the main source of distribution of the Cholera disease.

 [5]  Bompangue, D., Moore, S., Taty, N. et al. Description of the targeted water supply and hygiene response strategy implemented during the cholera outbreak of 2017–2018 in Kinshasa, DRC. BMC Infect Dis 20, 226 (2020). https://doi.org/10.1186/s12879-020-4916-0